Glialia: supplement based on micronized palmitoylethanolamide

Glialia contains palmitoylethanolamide (PEA) and luteolin, two molecules with anti-inflammatory and neuroprotective properties.

What is micronized PEA?

Micronized PEA, or ultramicronized palmitoylethanolamide, is a form of PEA that has been milled into very fine particles. This makes it more easily absorbed by the body. PEA is a fatty acid amide that is found naturally in the body for his anti-inflammatory and analgesic effects. It is found in many foods, including peanuts, soy, and eggs.

Micronized PEA is available as a dietary supplement and is taken orally. It is typically used to treat chronic pain conditions, such as arthritis, neuropathic pain, and back pain. It may also be helpful for reducing inflammation and improving mood.

Benefits of micronized PEA:

• Pain relief: PEA has been shown to be effective in reducing pain from a variety of conditions, including arthritis, neuropathic pain, and back pain.
• Anti-inflammatory effects: PEA can help reduce inflammation, which can be a major factor contributing to pain.
• Improved mood: PEA may also be helpful for improving mood and reducing symptoms of depression and anxiety.

Scientific evidence

Numerous scientific studies, conducted both in vitro and in vivo, have supported the effectiveness of PEA in a wide range of applications. Its benefits have been demonstrated in various fields of medicine, including:

• Pain: PEA has demonstrated effective analgesic properties in the treatment of pain of different origins, both acute and chronic.
• Inflammation: PEA modulates the inflammatory response, reducing the symptoms associated with various inflammatory diseases 
• Dermatology: PEA has shown efficacy in the treatment of various dermatological problems, such as itching, dermatitis, and alopecia.
• Neurology: PEA has shown positive effects in the treatment of neurological disorders, such as epilepsy and anxiety.
• Gastroenterology: PEA has shown beneficial properties in the treatment of gastrointestinal disorders, such as colitis and diarrhea.

The study "Effects of PEA-LUT on Frontal Lobe Functions and GABAergic Transmission in Long-Covid Patients (PL-PC19)" explores the efficacy of PEA-LUT in patients suffering from neurological symptoms of Long-Covid showing improvements in several neurological symptoms like pain, anxiety, depression, brain fog, and anosmia.

The study "Palmitoylethanolamide Associated With Luteolin in Frontotemporal Dementia Patients. A Randomized Controlled Trial (PEA-FTD)" evaluated the efficacy of a dietary supplement containing palmitoylethanolamide (PEA) and luteolin in the treatment of frontotemporal dementia (FTD). The researchers observed that patients treated with PEA-luteolin showed improvements in some cognitive functions compared to the control group. In particular, there was an improvement in the ability to perform daily activities, memory, and language.

Mechanism of action

The mechanism of action of PEA was baptized ALIA (Autacoid Local Injury Antagonism) by Professor Rita Levi Montalcini, its discoverer. ALIA is based on PEA's ability to modulate the production of autocoids, substances produced locally by tissues in response to trauma or aggression.

Activation of the ALIA system by PEA leads to:

• Reduction of inflammatory mediator production: PEA counteracts the production of pro-inflammatory molecules, helping to reduce inflammation.
• Modulation of the immune response: PEA regulates the activation of immune cells, favoring a balanced immune response.
• Cell protection: PEA exerts a protective action on cells, counteracting damage induced by oxidative stress and free radicals.

What is Glialia used for?

Glialia is used to treat a variety of conditions associated with neuroinflammation, including:

• Neurological disorders: Stroke, transient ischemic attacks, post-traumatic states, senile dementia (early stages), Parkinson's disease (early stages).
• Neuropathic pain: Diabetic neuropathic pain, chemotherapy-induced neuropathic pain, other forms of neuropathic pain.
• Mood disorders: Mood disorders such as anxiety and mild depression.

How does Glialia work?

Glialia works by reducing inflammation in the nervous system. It does this by:

• Inhibiting the production of inflammatory mediators: Glialia can inhibit the production of inflammatory molecules, such as cytokines and prostaglandins. These molecules contribute to inflammation and can damage nerve cells.
• Modulating the immune response: Glialia can modulate the immune response, helping to reduce inflammation and protect nerve cells from damage.
• Protecting nerve cells from damage: Glialia has antioxidant properties that can help protect nerve cells from damage caused by free radicals. Free radicals are molecules that can damage cells and contribute to the aging process.

What are the benefits of Glialia?

In addition to reducing inflammation, Glialia has a number of other potential benefits, including:

• Protecting brain cells from damage: The antioxidant action of Glialia helps to counteract the action of free radicals, which are responsible for cell aging and various neurodegenerative diseases.
• Improving cognitive function: Glialia may improve memory, concentration, and learning.
• Reduces stress and anxiety: The anxiolytic and anti-stress properties of Glialia may be helpful in managing everyday stress, anxiety, and mild depression.
• Supporting nervous system health: Glialia can improve sleep quality, reduce fatigue, and improve mood.

How to take Glialia

The recommended dosage is 400 mg of PEA and 40 mg of luteolin per day. Glialia can be taken with or without food.

Glialia may be a good option for people who are looking for a natural way to reduce inflammation and improve their nervous system health. However, it is important to talk to your doctor before taking Glialia, especially if you are pregnant, breastfeeding, or have any underlying health conditions.

Are there any side effects of Glialia?

Glialia is generally well-tolerated. However, some people may experience side effects such as nausea, vomiting, diarrhea, and headache. If you experience any side effects, stop taking Glialia and talk to your doctor.

Size of Glialia

Glialia sachets: These sachets contain a powder form of Glialia that can be mixed with water or juice. This format is ideal for people who prefer to take their supplements in a liquid form.

Glialia oral suspension: This oral suspension is a pre-mixed liquid form of Glialia that is easy to take. It is a good option for people who have difficulty swallowing tablets or capsules.

Glialia 400mg tablets: These tablets contain 400mg of PEA, the main active ingredient in Glialia. This format is a good option for people who want a precise dose of PEA.

Which format of Glialia is right for you?

The best format of Glialia for you will depend on your individual needs and preferences. If you are unsure which format is right for you, talk to your doctor or pharmacist.

Additional Information

Please note that Glialia is a supplement for special medical purposes and not a drug.

Bosciaclub online pharmacy is authorized by the Ministry of Health.

Our online pharmacists are available to provide information about micronized PEA.